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- Title
Self‐Assemble Polymeric Nanoparticle with GSH Exhaustion for SPECT Imaging–Guided Enhanced Radioisotope Therapy.
- Authors
Tao, Yugui; Ren, Pengfei; Yi, Xuan; Zhou, Hailin; Xiong, Saisai; Ge, Fei; Chen, Lei; Yang, Kai
- Abstract
Exploiting biocompatible nanomaterials for cancer theranostics has attracted great attention in recent years. Herein, a multifunctional self‐assembled nanoparticle based on a biocompatible polymer that contains 3‐(4‐hydroxyphenyl) propionic acid N‐hydroxysuccinimide ester (HOPA) for radiolabeling and piperlongumine (PL) for exhausting endogenous glutathione (GSH) (HOPA‐C18PMH‐PEG/PL) is successfully synthesized. With radionuclide 125I labeling, SPECT imaging shows high tumor uptake of HOPA‐C18PMH‐PEG/PL after intravenous injection. The in vitro and in vivo combined radioisotope therapy (RIT) and chemotherapy using 131I‐labeled HOPA‐C18PMH‐PEG/PL is then carried out, achieving synergistic antitumor effect. This is because the reactive oxygen species (ROS) level in the tumor sites of mice treated with 131I‐labeled HOPA‐C18PMH‐PEG/PL is increased after the exhaustion of GSH by PL. Additionally, such a strategy (exhausting GSH and increasing ROS) induces no obvious toxicity to normal tissue. Therefore, as‐made polymeric nanoparticles exhibit multifunctional properties for SPECT imaging–guided combined RIT and chemotherapy in one system. This finding will further promote polymeric nanoparticle–based RIT of cancer and is expected to be used for future clinical transformation.
- Subjects
RADIONUCLIDE imaging; RADIOISOTOPES; SINGLE-photon emission computed tomography; RADIOLABELING; PROPIONIC acid; INTRAVENOUS injections
- Publication
Particle & Particle Systems Characterization, 2019, Vol 36, Issue 6, pN.PAG
- ISSN
0934-0866
- Publication type
Article
- DOI
10.1002/ppsc.201900018