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- Title
Fragment-based labeling using condensation reactions of six potential 5-HT<sub>7</sub>R PET tracers.
- Authors
Tampio L'Estrade, Elina; Shalgunov, Vladimir; Lehel, Szabolcs; Nymann Petersen, Ida; Poulie, Christian Bernard Matthijs; Edgar, Fraser G.; Volk, Balázs; Ohlsson, Tomas; Erlandsson, Maria; Knudsen, Gitte M.; Herth, Matthias M.
- Abstract
In this work, a fragment-based labeling procedure was developed based on condensation reactions. Six 18F-labeled (arylpiperazinyl-butyl)oxindole derivatives were synthesized. These structures are interesting lead compounds with respect to development of a 5-HT7R PET tracer. They were radiolabeled in sufficient radiochemical yields, purities and molar activities for future in vivo evaluation in rodents.
- Subjects
CONDENSATION reactions; LABELS; POLYETHYLENE terephthalate; POSITRON emission tomography; LEAD compounds
- Publication
Journal of Radioanalytical & Nuclear Chemistry, 2020, Vol 326, Issue 3, p1749
- ISSN
0236-5731
- Publication type
Article
- DOI
10.1007/s10967-020-07475-0