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- Title
Preclinical indicators of autonomic nervous system activity in pediatric OSA.
- Authors
Dima-Cozma, Lucia Corina; Cozma, Sebastian; Lupușoru, Cătălina Elena; Patacchioli, Francesca Romana; Ghiciuc, Cristina Mihaela
- Abstract
Obstructive sleep apnea (OSA) syndrome, with an estimated prevalence of 1-6% in children, is characterized by hypothalamo-pituitaryadrenal axis dysregulation and earlier activation of the autonomic nervous system activity. The aim of the present study was to explore the interdependencies of the two axes and the reliability of salivary alpha-amylase as a noninvasive marker of autonomic nervous system activation. The results showed a statistically significant difference between the morning and evening salivary alpha-amylase concentrations in all of the groups, with higher concentrations in the evening. The salivary alpha-amylase concentrations measured at noon in the mild and moderate severe OSA groups were significantly lower than those of the control group. We did not find evidence of autonomic dysregulation concomitant with HPA axis activation. The differences with other studies from literature could be discussing taking in account that our cohort did not include obese children and the duration of the disease was not long enough. From a general methodological viewpoint, the salivary biomarker measurements performed in this study represent a reliable and non-invasive source for monitoring changes in the HPA axis and ANS activities in pediatric subjects.
- Subjects
AUTONOMIC nervous system diseases; SLEEP apnea syndromes in children; BIOINDICATORS
- Publication
ORL.ro, 2016, Vol 9, Issue 31, p40
- ISSN
2067-6530
- Publication type
Article