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- Title
Reaction of 2-(2-Oxo-1,2-dihydro-3H-pyrrol-3-ylidene)- malononitriles with C-Nucleophiles. Synthesis of New Spiro-Fused Pyrrole Derivatives.
- Authors
Milovidova, A. G.; Belikov, M. Yu.; Ievlev, M. Yu.; Ershov, O. V.; Nasakin, O. E.
- Abstract
Base-catalyzed nucleophilic addition of carbon nucleophiles to the exocyclic double bond of 2-(5-aryl-4-methyl-2-oxo-1,2-dihydro-3H-pyrrol-3-ylidene)malononitriles afforded spiro-fused pyrrole derivatives, 7-amino-3-aryl-4-methyl-1-oxo-8-oxa-2-azaspiro[4.5]deca-3,6,9-triene-6-carbonitriles. The products can be regarded as rare structural analogs of biologically active spirans based on isatin.
- Subjects
MALONONITRILE; NUCLEOPHILES; CHEMICAL reactions; PYRROLE derivatives; CHEMICAL synthesis
- Publication
Russian Journal of Organic Chemistry, 2018, Vol 54, Issue 12, p1790
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428018120084