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- Title
Photoredox‐Catalyzed Three‐Component Difluoroalkylation of Quinoxalin‐2(1H)‐ones with Unactivated Vinylarenes and [Ph<sub>3</sub>PCF<sub>2</sub>H]<sup>+</sup>Br<sup>−</sup>.
- Authors
Xu, Yuandong; Qu, Hongzhao; Yuan, Jinwei; Guo, Na; Yang, Liangru; Yin, Yanli; Qu, Lingbo; Mao, Jian
- Abstract
An efficient synthesis of a variety of 3‐difluoroalkyl quinoxalin‐2(1H)‐ones via a photoredox‐catalyzed three‐component reaction between quinoxalin‐2(1H)‐ones, vinylarenes, with inexpensive and easily accessible difluoromethyltriphenyl phosphonium bromide salt as the difluoromethylated reagent is described. This protocol shows excellent reactivity, providing a wide range of difluoroalkyl‐substituted quinoxalin‐2(1H)‐ones in moderate to excellent yields under mild conditions. A difluoroalkyl radical intermediate was involved in this three‐component transformation.
- Subjects
PHOSPHONIUM compounds; RADICALS (Chemistry)
- Publication
Asian Journal of Organic Chemistry, 2023, Vol 12, Issue 11, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202300405