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- Title
Qiliqiangxin Improves Cardiac Function through Regulating Energy Metabolism via HIF-1α-Dependent and Independent Mechanisms in Heart Failure Rats after Acute Myocardial Infarction.
- Authors
Wang, Yanyan; Fu, Mingqiang; Wang, Jingfeng; Zhang, Jingjing; Han, Xueting; Song, Yu; Fan, Yuyuan; Hu, Kai; Zhou, Jingmin; Ge, Junbo
- Abstract
The present study is aimed at investigating whether Qiliqiangxin (QL) could regulate myocardial energy metabolism in heart failure rats after acute myocardial infarction (AMI) and further exploring the underlying mechanisms. AMI was established by ligating the left anterior descending coronary artery in adult male SD rats. AMI rats with ejection fraction EF < 50 % at two weeks after the operation were chosen as heart failure rats for the main study. Rats were randomized into the sham, MI, MI+QL, and MI+QL+2-MeOE2 groups. The results showed that compared with the MI group, QL significantly improved cardiac function, reduced serum NT-proBNP level, and alleviated myocardial fibrosis. QL also increased myocardial capillary density by upregulated protein expressions of vascular endothelial growth factor (VEGF) and CD31 by regulating the HIF-1α/VEGF pathway. Moreover, QL promoted ATP production, glucose uptake, and glycolysis by upregulating HIF-1α and a series of glycolysis-relevant enzymes in a HIF-1α-dependent manner. QL also improved myocardial glucose oxidation enzyme expression and free fatty acid uptake by a HIF-1α-independent pathway. Our results indicate that QL treatment improves cardiac function through regulating glucose uptake, FFA uptake, and key enzymes of energy metabolism via HIF-1α-dependent and independent mechanisms.
- Subjects
ADENOSINE triphosphatase; ANIMAL experimentation; CARDIOVASCULAR system; CELL adhesion molecules; CELLULAR signal transduction; CORONARY arteries; ENERGY metabolism; FATTY acids; GENE expression; GLUCOSE; GLYCOLYSIS; HEART failure; HERBAL medicine; CHINESE medicine; MYOCARDIAL infarction; MYOCARDIUM; OXIDATION-reduction reaction; RATS; TRANSCRIPTION factors; VASCULAR endothelial growth factors; FIBROSIS; NATRIURETIC peptides; VENTRICULAR ejection fraction
- Publication
BioMed Research International, 2020, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2020/1276195