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- Title
IAA, GAD65 AND IA2 Antibodies In Type 1 Diabetes Mellitus Children And Adolescents.
- Authors
Khan, Yasir Naqi; Ashfaq, Muhammad; Bader-u-Nisa; Yasir, Mehrunnisa; Waseem, Hira; Kanpurwala, Muhammad Adnan
- Abstract
Objective: The objective of the study was to find out the association of Insulin Auto antibodies (IAA), glutamic acid decarboxylase (GAD65), and Insulinoma-Associated-2 Auto antibodies (IA-2A) antibodies in type 1 diabetes mellitus concern in gage, gender, and duration of disease. Methods: This was a retrospective study conducted at the department of endocrinology and diabetes by using nonprobability consecutive sampling technique, after taking ethical approval. The duration of the study was one year. A total of 143 individuals (both children and adolescents up to the age of 18 years) clinically diagnosed with type 1 diabetes were selected for the study where as those who were having any congenital and any other endocrine disorder were excluded. All study subjects were investigated for pancreatic autoimmune markers (GAD65, IA-2A, IAAs). Pearson's Chi-square test was applied to evaluate the association. Results: The study results showed that out of 143 individuals, 71 (49.7%) were males and 72 (50.3%) were females. Distribution of positivity of auto anti bodies showed that 27 (18.9%) had AntiInsulin IgG, 63 (44.1%) had GAD65, 47 (32.9%) had IA-2A and only 5 (3.5%) had a grey zone. There was a significant association was reported (p<0.001) in the duration of diabetes and with IAA. Furthermore, there was a statistically significant association with (p=0.003) duration of diabetes and frequency of IA-2A. Conclusion: This study concludes that the presence of autoantibodies such as insulinoma-associated antigen-2 autoantibodies, Insulin autoantibodies, and glutamic acid decarboxylase 65 predicts type-I diabetes mellitus in children and adolescents. Additionally, the presence of insulinoma-associated antigen- 2 autoantibodies, Insulin autoantibodies are significantly associated with the duration of disease.
- Subjects
TYPE 1 diabetes; DIABETES in children; GLUTAMATE decarboxylase; INSULIN antibodies; IMMUNOGLOBULINS
- Publication
Annals of Abbasi Shaheed Hospital & Karachi Medical & Dental College, 2021, Vol 26, Issue 3, p114
- ISSN
1563-3241
- Publication type
Article
- DOI
10.58397/ashkmdc.v26i3.474