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- Title
Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla.
- Authors
Wei, Xin; Jiang, Li-Ping; Guo, Ying; Khan, Afsar; Liu, Ya-Ping; Yu, Hao-Fei; Wang, Bei; Ding, Cai-Feng; Zhu, Pei-Feng; Chen, Ying-Ying; Zhao, Yun-Li; Chen, Yong-Bing; Wang, Yi-Fen; Luo, Xiao-Dong
- Abstract
Uncaria rhynchophylla is commonly recognized as a traditional treatment for dizziness, cerebrovascular diseases, and nervous disorders in China. Previously, the neuro-protective activities of the alkaloids from U. rhynchophylla were intensively reported. In current work, three new indole alkaloids ( 1-3), identified as geissoschizic acid ( 1), geissoschizic acid N -oxide ( 2), and 3 β-sitsirikine N -oxide ( 3), as well as 26 known analogues were isolated from U. rhynchophylla. However, in the neural stem cells (NSCs) proliferation assay for all isolated compounds, geissoschizic acid ( 1), geissoschizic acid N -oxide ( 2), isocorynoxeine ( 6), isorhynchophylline ( 7), (4 S)-akuammigine N-oxide ( 8), and (4 S)-rhynchophylline N-oxide ( 10) showed unexpected inhibitory activities at 10 μM. Unlike previous neuro-protective reports, as a warning or caution, our finding showcased a clue for possible NSCs toxicity and the neural lesions risk of U. rhynchophylla, while the structure-activity relationships of the isolated compounds were discussed also.
- Subjects
INDOLE alkaloids; NEURAL stem cells; UNCARIA; CELL proliferation; CEREBROVASCULAR disease
- Publication
Natural Products & Bioprospecting, 2017, Vol 7, Issue 5, p413
- ISSN
2192-2209
- Publication type
Article
- DOI
10.1007/s13659-017-0141-y