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- Title
The chemokine receptor CCR7 is expressed on epithelium of non-inflamed gastric mucosa,Helicobacter pylorigastritis, gastric carcinoma and its precursor lesions and up-regulated byH. pylori.
- Authors
Schmaußer, B.; Endrich, S.; Brändlein, S.; Schär, J.; Beier, D.; Müller-Hermelink, H.-K.; Eckt, M.
- Abstract
CCR7 chemokine-receptor expression on tumour cells of gastric carcinoma has been associated with lymph-node metastasis and is thought to play an important role in metastasis. However, so far it is unknown whether CCR7 is newly up-regulated on gastric carcinoma or already expressed in non-neoplastic gastric epithelium. Therefore, epithelial CCR7 expression was investigated in the process of gastric carcinogenesis: non-inflamed mucosa– Helicobacter pylorigastritis– intestinal metaplasia/dysplasia– gastric carcinoma. CCR7 was expressed by gastric epithelium in non-inflamed gastric mucosa (n = 5),H. pylorigastritis (n = 17), intestinal metaplasia (n = 10), dysplasia (n = 3) and on tumour cells in 20 of 24 patients with gastric carcinoma (13/14 intestinal-type; 7/10 diffuse-type) as tested by immunohistochemistry. As CCR7 expression by gastric epithelium was significantly stronger inH. pylorigastritis than in non-infected mucosa, the influence ofH. pylorion CCR7 receptor expression of gastric epithelial cells was investigated by fluorescence activated cell sorter analysis.H. pyloristrains up-regulated the CCR7 chemokine-receptor in CCR7-positive cell lines. No difference in CCR7 up-regulation betweencag+ andcag– H. pyloristrains was found. Epithelial CCR7 up-regulation byH. pylorimay alter the metastatic fate of gastric carcinoma. Additionally, CCR7 expression not only on gastric carcinoma, but also on non-neoplastic gastric epithelium, suggests a novel biological function.
- Subjects
CHEMOKINES; INFLAMMATORY mediators; CANCER; METASTASIS; TUMORS; GASTRIC mucosa
- Publication
Clinical & Experimental Immunology, 2005, Vol 139, Issue 2, p323
- ISSN
0009-9104
- Publication type
Article
- DOI
10.1111/j.1365-2249.2005.02703.x