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- Title
CXC chemokines Groα/IL-8 and IP-10/MIG inHelicobacter pylori gastritis.
- Authors
Eck, M.; Schmausser, B.; Scheller, K.; Toksoy, A.; Kraus, M.; Menzel, T.; Müller-Hermelink, H. K.; Gillitzer, R.
- Abstract
Infection with Helicobacter pylori causes chronic active gastritis, which is characterized by neutrophils infiltrating the gastric epithelial layer and the underlying lamina propria as well as by T, B lymphocytes and macrophages accumulating in the lamina propria. In this study, the chemokine profile responsible for the recruitment of these inflammatory cells is investigated. Using both RNA/RNA in situ hybridization and immunohistochemistry, the expression of the neutrophil and/or lymphocyte-attractant CXC chemokines growth-related oncogene alpha (Groα), IL-8, interferon-gamma (IFN-γ)-inducible protein-10 (IP-10), monokine induced by IFN-γ (MIG) and the CC chemokines macrophage inflammatory protein-1α (MIP-1α), -1β, regulated on activation normal T cell expressed and secreted (RANTES) and monocyte chemoattractant protein-1 (MCP-1) is studied and microanatomically localized in the gastric mucosa. Macrophages in the lamina propria at sites with neutrophil infiltration and gastric epithelium infiltrated by neutrophils highly expressed the neutrophil-attractant chemokines Groα and IL-8. Additionally, Groα and IL-8 were expressed by neutrophils themselves localized within gastric epithelium, in the foveolar lumen and in the cellular debris overlying mucosal erosion. IP-10 and to a lower extent MIG, both selectively chemotactic for inflammatory T cells, were expressed by endothelial cells of gastric mucosal vessels and by mononuclear cells at sites with T cell infiltration. Expression of all other CC chemokines tested was significantly lower. These in vivo data indicate that a set of predominantly CXC chemokines modulates the inflammation in H. pylori gastritis. Groα and IL-8 may play an important role in neutrophil trafficking from the mucosal vessel into the gastric epithelium, whereas IP-10 and MIG contribute to the recruitment of inflammatory T cells into the mucosa.
- Subjects
CHEMOKINES; GASTRITIS; HELICOBACTER pylori infections
- Publication
Clinical & Experimental Immunology, 2000, Vol 122, Issue 2, p192
- ISSN
0009-9104
- Publication type
Article
- DOI
10.1046/j.1365-2249.2000.01374.x