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- Title
High-dose busulfan, cyclophosphamide, and etoposide does not improve outcome of allogeneic stem cell transplantation compared to BuCy2 in patients with acute myeloid leukemia.
- Authors
Farag, S. S.; Bolwell, B. J.; Elder, P. J.; Kalaycio, M.; Lin, T.; Pohlman, B.; Penza, S.; Marcucci, G.; Blum, W.; Sobecks, R.; Avalos, B. R.; Byrd, J. C.; Copelan, E.
- Abstract
Summary:To reduce relapse following allogeneic transplantation for AML, intensification of high-dose busulfan/cyclophosphamide using additional agents has been investigated but with few reported comparisons. We compared an intensified regimen of etoposide (60?mg/kg), busulphan (14?mg/kg), and cyclophosphamide (120?mg/kg) (BuCyVP) with BuCy2 in 237 AML patients. No significant difference in overall outcome was observed following BuCyVP (n=127) or BuCy2 (n=110). The 5-year survival was 27.3 and 30.1%following BuCyVP and BuCy2, respectively (P=0.48). Similarly, the 5-year cumulative incidence of relapse (CIR) was 28.3 and 34.8%with BuCyVP and BuCy2 (P=0.45), respectively. On multivariable analysis, patients transplanted in CR1 (P=0.002) and from related donors (P=0.013) had longer survival, while disease status at transplant was the only factor predicting CIR (P=0.002). In a separate analysis of CR1 patients (n=56), there was no significant difference in survival (P=0.37) or CIR (P=0.87) between the two regimens. However, for more advanced disease, there was a trend towards less relapse with BuCyVP (P=0.08), which was balanced by a higher cumulative incidence of transplant-related deaths (P=0.03) compared to BuCy2, resulting in similar survival. Overall, our results do not support the use of the more intensive BuCyVP regimen over BuCy2 in either early or more advanced disease AML patients.Bone Marrow Transplantation (2005) 35, 653-661. doi:10.1038/sj.bmt.1704867 Published online 14 February 2005
- Subjects
ACUTE myeloid leukemia; ETOPOSIDE; ANTINEOPLASTIC agents; STEM cells; TRANSPLANTATION of organs, tissues, etc.; MYELOID leukemia; BONE marrow
- Publication
Bone Marrow Transplantation, 2005, Vol 35, Issue 7, p653
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1704867