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- Title
Impact of Neoadjuvant Treatment on Body Composition in Patients with Locally Advanced Gastric Cancer.
- Authors
Juez, Luz Divina; Priego, Pablo; Cuadrado, Marta; Blázquez, Luis A.; Sánchez-Picot, Silvia; Gil, Pablo; Longo, Federico; Galindo, Julio; Fernández-Cebrián, José María; Botella-Carretero, José I.
- Abstract
Simple Summary: Neoadjuvant chemotherapy (NT) followed by radical surgery is the standard treatment for locally advanced gastric cancer (GC). The impact of NT on body composition was analyzed in locally advanced GC patients undergoing gastrectomy. During chemotherapy, GC patients experienced loss of muscle mass and fat, leading to an increased incidence of pre-surgical sarcopenia. Neoadjuvant chemotherapy (NT) followed by radical surgery is the standard treatment for locally advanced gastric cancer (GC). The incidence of sarcopenia in upper gastrointestinal tract malignancies is very high, and it may be increased after NT. This study aimed to evaluate the impact of NT on body composition. A retrospective study of patients with locally advanced GC undergoing gastrectomy who had received NT in a tertiary hospital between 2012 and 2019 was conducted. CT measured the skeletal muscle index, total psoas area, and visceral and subcutaneous adipose tissue before and after NT. Of the 180 gastrectomies for GC, 61 patients received NT. During NT, changes in body composition were observed with a decrease in the skeletal muscle mass index (SMMI −2.5%; p < 0.001), and these changes were significantly greater in men (SMMI −10.55%). Before surgery, patients who received NT presented 15% more sarcopenia than those without NT (p = 0.048). In conclusion, patients with locally advanced gastric cancer who receive NT have significant changes in body composition during chemotherapy. These changes, which are at the expense of a loss of muscle mass, lead to an increased incidence of pre-surgical sarcopenia.
- Subjects
PREOPERATIVE period; STOMACH tumors; RESEARCH funding; SKELETAL muscle; PSOAS muscles; ADIPOSE tissues; BODY mass index; BODY composition; COMPUTED tomography; SEX distribution; TREATMENT effectiveness; RETROSPECTIVE studies; TERTIARY care; CANCER chemotherapy; PRE-tests &; post-tests; COMBINED modality therapy; SARCOPENIA
- Publication
Cancers, 2024, Vol 16, Issue 13, p2408
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers16132408