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- Title
Circulating Markers of Inflammation and Their Link to Indices of Adiposity.
- Authors
Browning, Lucy M.; Krebs, Jeremy D.; Magee, Edel C.; Frühbeck, Gema; Jebb, Susan A.
- Abstract
Background: Adipose tissue produces a number of inflammatory mediators. Circulating concentrations of these inflammatory markers are increasingly used as markers of local or systemic inflammation. This study compares results for 3 inflammatory adipokines measured using 2 techniques, (multiplex and ELISA), and determines the relationships with C-reactive protein (CRP), obesity, and the impact of moderate weight loss. Subjects and Methods: Fasting blood samples were collected at baseline and after a 24-week weight loss intervention. Interleukin 6 (IL-6), tumour necrosis factor α(TNF-α), and monocyte chemoattractant protein 1 (MCP-1) were measured using a standard ELISA technique or a new multiplex technique. A total of 54 women with complete data were included in this analysis. Results: Multiplex showed poor correlation with ELISA results, and were not significantly correlated with CRP. Using ELISA data, IL-6 and CRP were significantly correlated with body mass index (BMI) (r = 0.42 and r = 0.55), but MCP-1 and TNF-αwere not (r = - 0.07 and r = 0.06). Changes in MCP-1, TNF-α, and IL-6 were not significantly different between control and weight loss groups. CRP was significantly reduced in weight loss vs. control group (p < 0.05), and change in CRP correlated with change in BMI (r = 0.31). Conclusion: Circulating IL-6 and CRP, but not MCP-1 and TNF-α, are significantly associated with indices of adiposity in obese women. This study suggests that circulating IL-6 and CRP, but not MCP-1 and TNF-α, are useful markers of obesity-related inflammation. Copyright © 2008 S. Karger AG, Basel
- Publication
Obesity Facts: The European Journal of Obesity, 2008, Vol 1, Issue 5, p259
- ISSN
1662-4025
- Publication type
Article
- DOI
10.1159/000169832