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- Title
Synthesis, Characterization, and Biological Activity of 4-(2-Hydroxy-5-(aryl-diazenyl)phenyl)-6-(aryl)pyrimidin-2-ols Derivatives.
- Authors
Pandhurnekar, Chandrashekhar P.; Meshram, Ekta M.; Chopde, Himani N.; Batra, Rameshkumar J.
- Abstract
With the aim of synthesizing new heterocyclic compounds and exploring biological potency, new series of chalcones, that is, 3-(2-hydroxy-5-(aryl-diazenyl)phenyl)-1-(aryl)prop-2-en-1-one and their pyrimidine derivatives, that is, 4-(2-hydroxy-5-(aryldiazenyl) phenyl)-6-(aryl)pyrimidin-2-ols were synthesized using different aromatic amines and salicylaldehyde as starting moieties. The structures of newly synthesized compounds were confirmed using different spectroscopic techniques such as IR, 1H-NMR, 13C-NMR, and mass spectral analysis, and elemental analysis. The newly synthesized pyrimidines derivatives were screened for their in vitro antibacterial and antifungal activities. It was observed that some of the newly synthesized compounds had shown promising activity against several bacterial and fungal stains. Anti-bacterial activity and anti-fungal activity studies revealed that pyrimidine derivatives consisting of nitro group in their molecular structure possess better activity than their corresponding chalcones.
- Subjects
PYRIMIDINE derivatives; PYRIMIDINE synthesis; PHENYL compounds; HETEROCYCLIC compounds; CHALCONES
- Publication
Organic Chemistry International, 2013, p1
- ISSN
2090-200X
- Publication type
Article
- DOI
10.1155/2013/582079