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- Title
Regulatory Τ-cell Differentiation Between Maternal and Cord Blood Samples in Pregnancies with Spontaneous Vaginal Delivery and with Elective Cesarian Section.
- Authors
Bili, Helen; Fleva, Alexandra; Pados, George; Argyriou, Theodoros; Tsolakidis, Dimitrios; Pavlitou, Aikaterini; Tarlatzis, Basil C.
- Abstract
Bili H, Fleva A, Pados G, Argyriou T, Tsolakidis D, Pavlitou A, Tarlatzis BC. Regulatory T-cell differentiation between maternal and cord blood samples in pregnancies with spontaneous vaginal delivery and with elective cesarian section. Am J Reprod Immunol 2011; 65: 173-179 The immunological mechanisms preventing fetal antigenic rejection during normal pregnancy and the extent to which the type of delivery influences lymphocyte reactions are elusive. Maternal peripheral blood and neonatal umbilical cord blood (CB) was collected upon labor after vaginal delivery or cesarian section. Leukocytes were analyzed with flow cytometry, focusing on regulatory and γ/δ T-cells. In CB from neonates delivered by vaginal delivery, natural killer cells were increased. On the other hand, in maternal blood, γ/δ T-cells were increased, and activated T-cells (cluster of differentiation [CD]4+/25/122+ cells) were decreased. Moreover, maternal blood presented increased levels of T regulatory cell subsets like CD4+/25/45RO+, CD4+/25/DR+, CD4+/25/CD38+ and CD4+/25/71+. In CB, CD19+, CD4+/25/45RA+ and CD4+/25/122+ cells were increased. The effect of delivery type on lymphocyte immunophenotype was minimal. Mothers' and neonates' lymphocyte subsets differed significantly. Mothers' phenotype comprised significantly of lymphocytes involved in tolerance (memory and activated regulatory T-cells, γ/δ T-cells).
- Subjects
T cell differentiation; CELL differentiation; CORD blood; PREGNANCY; DELIVERY (Obstetrics)
- Publication
American Journal of Reproductive Immunology, 2011, Vol 65, Issue 2, p173
- ISSN
1046-7408
- Publication type
Article
- DOI
10.1111/j.1600-0897.2010.00910.x