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- Title
Evaluation of NLRP3 and IL-18 Levels after Periodontal Therapy.
- Authors
Shahbeik, Shahrzad; Taleghani, Ferial; Sattari, Mandana; Mohammadi, Mahyar Mahvash; Moravej, Mohammadreza; Mahvash Mohammadi, Mahyar; Moravej, Mohamadreza
- Abstract
The progression of periodontitis depends on interactions between the periodontal pathogens and the host immune cytokines, including interleukin (IL)-1β and IL-18. Production of IL-1β is regulated by NOD-like receptors family pyrin domain containing 3 (NLRP3). This study aimed to evaluate the effect of periodontal treatment on the concentrations of IL-18 and NLRP3 in patients with chronic periodontitis. In this experimental study, 18 patients with chronic periodontitis and a mean age of 46.2±8.95 years, were included. The gingival crevicular fluid (GCF) was collected at the beginning of the study, 4 weeks after non-surgical (phase I), and 4 weeks after surgical periodontal treatment. The levels of NLRP3 and IL-18 were measured; using an enzyme-linked immunosorbent assay. Pearson correlation test was used to analyze the concentration of NLRP3 and IL-18 before and after the treatments with CAL and PD. There was a significant association between the level of NLRP3 and the mean values of PD and CAL before treatment. After each treatment phase, a significant decrease was observed in the NLRP3 level. There was no significant relationship between IL-18 and clinical parameters before and after periodontal treatments. Given the possible association between the level of NLRP3 and clinical parameters, we suggest it as a possible indicator of inflammation in chronic periodontitis and an index for evaluating the treatment outcome.
- Subjects
TOOTH root planing; NLRP3 protein; ENZYME-linked immunosorbent assay; GINGIVAL fluid
- Publication
Iranian Journal of Allergy, Asthma & Immunology, 2021, Vol 20, Issue 6, p764
- ISSN
1735-1502
- Publication type
journal article
- DOI
10.18502/ijaai.v20i6.8028