We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Outcome of patients with heart failure after transcatheter aortic valve implantation.
- Authors
Fischer-Rasokat, Ulrich; Renker, Matthias; Liebetrau, Christoph; Weferling, Maren; Rolf, Andreas; Doss, Mirko; Möllmann, Helge; Walther, Thomas; Hamm, Christian W.; Kim, Won-Keun
- Abstract
Aims: Patients with aortic stenosis (AS) may have concomitant heart failure (HF) that determines prognosis despite successful transcatheter aortic valve implantation (TAVI). We compared outcomes of TAVI patients with low stroke volume index (SVI) ≤35 ml/m2 body surface area in different HF classes. Methods and results: Patients treated by transfemoral TAVI at our center (n = 1822) were classified as 1) 'HF with preserved ejection fraction (EF)' (HFpEF, EF ≥50%), 2) 'HF with mid-range EF' (HFmrEF, EF 40–49%), or 3) 'HF with reduced EF' (HFrEF, EF <40%). Patients with SVI >35 ml/m2 served as controls. The prevalence of cardiovascular disease and symptoms increased stepwise from controls (n = 968) to patients with HFpEF (n = 591), HFmrEF (n = 97), and HFrEF (n = 166). Mortality tended to be highest in HFrEF patients 30 days post-procedure, and it became significant after one year: 10.2% (controls), 13.5% (HFpEF), 13.4% (HFmrEF), and 23.5% (HFrEF). However, symptomatic improvement in survivors of all groups was achieved in the majority of patients without differences among groups. Conclusions: Patients with AS and HF benefit from TAVI with respect to symptom alleviation. TAVI in patients with HFpEF and HFmrEF led to an identical, favorable post-procedural prognosis that was significantly better than that of patients with HFrEF, which remains a high-risk population.
- Subjects
HEART valve prosthesis implantation; HEART failure patients; ARTIFICIAL hearts; DIALYSIS catheters; BODY surface area; AORTIC stenosis; HEART disease related mortality
- Publication
PLoS ONE, 2019, Vol 14, Issue 11, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0225473