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- Title
Cerebellar antibodies in post-stroke sera of acute ischemic stroke patients.
- Authors
ATMACA, Murat Mert; ERDAĞ, Ece; DEMIR, Serkan; YÜCEER, Hande; ATMACA, Melek Çolak; KÜÇÜKALI, Cem İsmail; KÜRTÜNCÜ, Murat; TÜZÜN, Erdem
- Abstract
Background and purpose - Although serum anti-neuronal antibodies are found in acute ischemic stroke (AIS) patients, it is not completely clear whether they are already present before the cerebrovascular event or emerge thereafter. Methods - Sera of 21 consecutive firstever AIS patients were collected within the first day of AIS (baseline), as well as 1 and 6 months after AIS. Well-characterized and novel anti-neuronal antibodies were investigated by cell-based assays, immunoblotting and indirect immunohistochemistry. Results - None of the AIS sera collected at different time points showed well-characterized antibodies. In 7 patients, 1- and 6-month sera (but not baseline sera) showed IgG mostly reacting with soma and dendrites of cerebellar Purkinje cells. Antibody-positive patients did not differ in terms of clinical and etiological features. Conclusion - Our results provide evidence for the antibody-triggering action of AIS. Although anti-cerebellar antibodies are not associated with the severity of stroke, they may potentially contribute to chronic poststroke complications and disability.
- Subjects
STROKE patients; ISCHEMIC stroke; PURKINJE cells; IMMUNOGLOBULINS; STROKE
- Publication
Clinical Neuroscience / Ideggyógyászati Szemle, 2023, Vol 76, Issue 11/12, p394
- ISSN
0019-1442
- Publication type
Article
- DOI
10.18071/isz.76.0394