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- Title
Capsaicin-sensitive sensory neurons regulate myocardial function and gene expression pattern of rat hearts: a DNA microarray study.
- Authors
Zvara, Ágnes; Bencsik, Péter; Fodor, Gabriella; Csont, Tamás; Hackler Jr., László; Dux, Mária; Fürst, Susanna; Jancsó, Gábor; Puskás, László G.; Ferdinandy, Péter
- Abstract
The article presents information on a DNA microarray study explaining that capsaicin-sensitive sensory neurons regulate myocardial function and gene expression pattern of rat hearts. It was discussed that capsaicin-induced chemodenervation resulted in an up-regulation of its own receptor, TRPV1, and other transient receptor potential protein-related genes. It was also explained that gene expression changes obtained by microarray assay were verified by RT-PCR in case of 10 selected genes with high biological significance.
- Subjects
DNA microarrays; CAPSAICIN; GENE expression; BIOCHIPS; IMMOBILIZED nucleic acids; HOT peppers
- Publication
FASEB Journal, 2006, Vol 20, Issue 1, p160
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.05-4060fje