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- Title
Fast highly efficient 'on-solvent' non-catalytic cascade transformation of benzaldehydes and 4-hydroxycoumarin into bis(4-hydroxycoumarinyl)arylmethanes.
- Authors
Elinson, Michail N.; Vereshchagin, Anatoly N.; Sokolova, Olga O.
- Abstract
Non-catalytic cascade reaction of benzaldehydes and two equivalents of 4-hydroxycoumarin initiated by reflux in propanol results in the fast (15 min) and efficient formation of substituted tetrahydro-1H-xanthen-1-ones in 93-98% yields. The developed fast cascade approach to the substituted bis(4- hydroxycoumarinyl)arylmethanes, which are known as medicinally relevant substances with anti-HIV, antibiotic, anti-inflammatory and anti-cancer activity, is beneficial from the viewpoint of diversity-oriented large-scale processes and represents fast, efficient and environmentally benign synthetic concept for cascade reactions strategy.
- Subjects
BENZENE compounds; CARBANIONS; SUSTAINABLE chemistry; BENZALDEHYDE; PROPANOLS
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2017, Vol 2017, p121
- ISSN
1551-7004
- Publication type
Article
- DOI
10.3998/ark.5550190.p010.023