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- Title
Radioprotective properties of eckol against ionizing radiation in mice
- Authors
Park, Eunjin; Ahn, Gin-nae; Lee, Nam Ho; Kim, Jeong Mi; Yun, Jin Seok; Hyun, Jin Won; Jeon, You-Jin; Wie, Myung Bok; Lee, Young Jae; Park, Jae Woo; Jee, Youngheun
- Abstract
Abstract: We have investigated the radioprotective efficacy of eckol, a component of brown seaweed Ecklonia cava, against the gamma ray-induced damage in vivo. Our results showed that eckol significantly decreased the mortality of lethally irradiated mice. The mechanisms of eckol’s protection were found to include: an improvement in hematopoietic recovery, the repair of damaged DNA in immune cells and an enhancement of their proliferation, which had been severely suppressed by ionizing radiation. Thus, we propose eckol as a candidate for adjuvant therapy to alleviate radiation-induced injuries to cancer patients.
- Subjects
RADIATION-protective agents; IONIZING radiation; ADJUVANT treatment of cancer; MARINE algae
- Publication
FEBS Letters, 2008, Vol 582, Issue 6, p925
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.02.031