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- Title
PD-L1 expression in immune cells is a favorable prognostic factor for nasopharyngeal carcinoma.
- Authors
Şahinli, Hayriye; Akyürek, Nalan; Yılmaz, Mukaddes; Kandemir, Olcay; Duran, Ayşe Ocak; Kulaçoğlu, Sezer; Uçar, Gökhan; Acar, Elif; Özet, Ahmet; Gümüş, Mahmut; Öksüzoğlu, Ö. Berna Ç.; Özdemir, Nuriye Y.; Sahinli, Hayriye; Ç Öksüzoğlu, Ö Berna
- Abstract
<bold>Background: </bold>Programmed death-ligand 1 (PD-L1) has been determined as a reliable prognostic factor for various malignancies. In this study, we aimed to determine the prognostic effect of PD-L1 expression in tumor-infiltrating immune cells (TIICs) of nasopharyngeal carcinoma (NPC) patients.<bold>Methods: </bold>Seventy patients diagnosed with non-metastatic NPC were included in the study. PD-L1 expression on immune cells was analyzed by immunohistochemical method. Patients were categorized into two groups according to the PD-L1 expression level in TIICs (level of PD-L1 staining ≥5% positive vs <5% negative).<bold>Results: </bold>Median follow-up period was 34 months (range = 1 - 188). 1 and 2 years survival rate were found as 75% and 63% in PD-L1 negative TIICs group (47%), and 85% and 83% in PD-L1 positive TIICs group (53%), respectively. PD-L1 positivity in immune cells (ICs) was detected in 53% of the patients. The survival rate was found better in the PD- L1 positive group compared to the negative group (P = 0.049).<bold>Discussion: </bold>In conclusion, the survival rate was found significantly better in the PD-L1 positive TIICs group, compared to the negative group.
- Subjects
NASOPHARYNX cancer; PROGRAMMED death-ligand 1; TUMOR-infiltrating immune cells; PROGNOSIS; SURVIVAL rate; SURVIVAL
- Publication
Indian Journal of Cancer, 2021, Vol 58, Issue 4, p561
- ISSN
0019-509X
- Publication type
journal article
- DOI
10.4103/ijc.IJC_459_19