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- Title
Long-term effect of maternal HBeAg on delayed HBeAg seroconversion in offspring with chronic hepatitis B infection.
- Authors
Tseng, Yu-Ru; Wu, Jia-Feng; Ni, Yen-Hsuan; Chen, Huey-Ling; Chen, Chih-Cheng; Wen, Wan-Hsin; Hsu, Hong-Yuan; Chang, Mei-Hwei
- Abstract
Background and aims: This cohort study investigated the long-term effect of maternal hepatitis B virus (HBV) sero-status on the spontaneous HBeAg seroconversion in offspring with chronic HBV infection. Methods: A total of 185 HBeAg-positive chronic HBV-infected children, with maternal HBV seromarkers checked, were enrolled. The median age at enrolment and follow-up duration was 5.7 years (range, neonate to 16.5 years) and 20.2 years (range, 4.2-31.0 years) respectively. These children were grouped according to the initial maternal HBsAg and HBeAg status: (i) children of non-carrier mothers ( n=48); (ii) children of HBeAg-negative chronic HBV-infected mothers ( n=57); (iii) children of HBeAg-positive chronic HBV-infected mothers ( n=80). HBV seromarkers and liver function profiles of these children were performed at 6-month intervals. Results: One hundred and twenty-one (65.4%) subjects had achieved spontaneous HBeAg seroconversion at the end of this follow-up study. Spontaneous HBeAg seroconversion was achieved in 83.3% of children with non-carrier mothers, 73.7% of children with HBeAg-negative chronic HBV-infected mothers and 48.8% of children with HBeAg-positive mothers during similar duration ( P<0.001). Positive maternal HBeAg and genotype C were associated with delayed spontaneous HBeAg seroconversion in multivariate analysis ( P=0.01 and P=0.002 respectively). In children of HBeAg-positive chronic HBV-infected mothers, persistent presence of maternal HBeAg showed a trend of association with delayed HBeAg seroconversion in their offspring ( P=0.06). Children of late maternal HBeAg seroconversion (>40 years old) had delayed HBeAg seroconversion compared with those of early HBeAg seroconversion mothers ( P=0.06). Conclusions: Persistence of maternal HBeAg is an important risk factor for delayed spontaneous HBeAg seroconversion in children with chronic HBV infection.
- Subjects
HEPATITIS B; NEONATAL diseases; MULTIVARIATE analysis; MOTHERS; CHRONIC diseases
- Publication
Liver International, 2011, Vol 31, Issue 9, p1373
- ISSN
1478-3223
- Publication type
Article
- DOI
10.1111/j.1478-3231.2011.02574.x