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- Title
Subclinical non-autoimmune hypothyroidism in children with steroid resistant nephrotic syndrome.
- Authors
Kapoor, Kanika; Saha, Abhijeet; Dubey, N.; Goyal, Parul; Suresh, C.; Batra, Vinita; Upadhayay, Ashish
- Abstract
Background: Thyroid status has not been studied well in children with steroid resistant nephrotic syndrome (SRNS). Methods: In this cross sectional study we recruited 20 children aged 1-16 years with SRNS and similar number of controls. Serum levels of FT3, FT4 and TSH were measured in all the subjects. Overt hypothyroidism was defined as low FT4 (normal values: 0.7-2.0 ng/mL) and elevated serum TSH above reference values (0.45-4.5 mIU/L). Subclinical hypothyroidism (SH) was defined as an elevation in serum TSH with a normal serum FT4 concentration. The primary outcome measure was serum levels of FT3, FT4 and TSH in children with SRNS. Results: Thirty per cent of the children ( n = 6) with SRNS had non-autoimmune subclinical hypothyroidism (2 children each with grade I, II and III). Children with SRNS had a median TSH value [3.9 mIU/L (0.5-13)] within normal range, but levels were high as compared to controls. Out of 6 children with SH, 3 were in partial remission, 3 were in complete remission. The TSH levels normalized on thyroxine supplementation in grades II and III subclinical hypothyroidism. Conclusion: Subclinical non-autoimmune hypothyroidism is present in a significant proportion of children with SRNS despite partial or complete remission. Thyroid profile should be evaluated routinely in this subset of patients.
- Subjects
AUTOIMMUNE diseases; STEROID drugs; NEPHROTIC syndrome; HYPOTHYROIDISM in children; THYROID gland physiology; CROSS-sectional method; HEALTH outcome assessment; DISEASE remission
- Publication
Clinical & Experimental Nephrology, 2014, Vol 18, Issue 1, p113
- ISSN
1342-1751
- Publication type
Article
- DOI
10.1007/s10157-013-0800-1