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- Title
Tremella fuciformis Inhibits Melanogenesis in B16F10 Cells and Promotes Migration of Human Fibroblasts and Keratinocytes.
- Authors
JO-HUA CHIANG; FUU-JEN TSAI; TSAI-HSIU LIN; JAI-SING YANG; YU-JEN CHIU
- Abstract
Background/Aim: Natural skin whiteners have been investigated for centuries. The development of preparations that safely achieve whitening of hyperpigmented skin lesions is a challenge for the cosmetics industry. Furthermore, promoting rapid wound healing and minimizing inflammation in injured skin are key to prevent from abnormal pigmentation in scar tissue. Natural products, including the fungus Tremella fuciformis (TF), are attracting attention as potential sources of lead compounds for these applications. Materials and Methods: We investigated the in vitro effects of TF on melanogenesis in murine B16F10 cells. Melanin and tyrosinase levels were measured after treatment with TF. Wound healing in human keratinocytes (HaCaT) and fibroblasts (Detroit 551) was also determined via cell migration assay prior to TF exposure. Results: TF significantly decreased melanin content and tyrosinase expression in a concentrationdependent manner in B16F10 cells. Furthermore, TF promoted wound healing in human HaCaT keratinocytes and Detroit 551 fibroblasts. Conclusion: TF proved effectively on inhibiting melanogenesis and promoting wound healing in vitro, demonstrating its potential as a novel skin-whitening agent. However, further clinical studies of safety and efficacy are required.
- Subjects
TREMELLA fuciformis; MELANOGENESIS; CELL migration; KERATINOCYTES; PHENOL oxidase; WOUND healing
- Publication
In Vivo, 2022, Vol 36, Issue 2, p713
- ISSN
0258-851X
- Publication type
Article
- DOI
10.21873/invivo.12757