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- Title
Functional Mitral and Tricuspid Regurgitation across the Whole Spectrum of Left Ventricular Ejection Fraction: Recognizing the Elephant in the Room of Heart Failure.
- Authors
Cammalleri, Valeria; Antonelli, Giorgio; De Luca, Valeria Maria; Carpenito, Myriam; Nusca, Annunziata; Bono, Maria Caterina; Mega, Simona; Ussia, Gian Paolo; Grigioni, Francesco
- Abstract
Functional mitral regurgitation (FMR) and tricuspid regurgitation (FTR) occur due to cardiac remodeling in the presence of structurally normal valve apparatus. Two main mechanisms are involved, distinguishing an atrial functional form (when annulus dilatation is predominant) and a ventricular form (when ventricular remodeling and dysfunction predominate). Both affect the prognosis of patients with heart failure (HF) across the entire spectrum of left ventricle ejection fraction (LVEF), including preserved (HFpEF), mildly reduced (HFmrEF), or reduced (HFrEF). Currently, data on the management of functional valve regurgitation in the various HF phenotypes are limited. This review summarizes the epidemiology, pathophysiology, and treatment of FMR and FTR within the different patterns of HF, as defined by LVEF.
- Subjects
MITRAL valve insufficiency; HEART failure; VENTRICULAR ejection fraction; VENTRICULAR dysfunction; HEART failure patients
- Publication
Journal of Clinical Medicine, 2023, Vol 12, Issue 9, p3316
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm12093316