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- Title
Clinical Impact of the Fracture Risk Assessment Tool on the Treatment Decision for Osteoporosis in Patients with Knee Osteoarthritis: A Multicenter Comparative Study of the Fracture Risk Assessment Tool and World Health Organization Criteria.
- Authors
Kim, Bo Young; Kim, Hyoun-Ah; Jung, Ju-Yang; Choi, Sang Tae; Kim, Ji-Min; Kim, Sang Hyon; Kwon, Seong-Ryul; Suh, Chang-Hee; Kim, Sung-Soo
- Abstract
Background: To compare the frequency of high-risk osteoporotic fracture in patients with knee OA (OA) using the fracture risk assessment tool (FRAX) and the bone mineral density (BMD). Methods: We retrospectively assessed 282 Korean patients with knee OA who visited five medical centers and 1165 healthy controls (HCs) aged ≥50 years without knee OA. After matching for age, sex, and body mass index, 478 subjects (239 patients with knee OA and 239 HCs) were included. Results: Based on the BMD, the frequency of osteoporosis was 40.2% in patients with knee OA and 36.4% in HCs. The predicted mean FRAX major osteoporotic fracture probabilities calculated with or without femur neck BMD differed significantly between the knee OA and HCs (6.9 ± 3.8% versus 6.1 ± 2.8%, p = 0.000 and 8 ± 3.6% versus 6.8 ± 2.3%, p < 0.001, respectively). The mean FRAX hip fracture probabilities calculated with or without femur neck BMD differed significantly in the knee OA and HCs (2.1 ± 2.4% versus 1.7 ± 1.8%, p = 0.006 and 3 ± 2.3% versus 2.4 ± 1.6%, p < 0.001, respectively). Conclusion: Our study suggests that FRAX may have a clinical impact on treatment decisions to reduce osteoporotic facture in patients with knee OA.
- Subjects
WORLD Health Organization; FEMUR neck; OSTEOARTHRITIS; KNEE; BONE density; RISK assessment; BODY mass index; PERIPROSTHETIC fractures
- Publication
Journal of Clinical Medicine, 2019, Vol 8, Issue 10, p918
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm8070918