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- Title
EXPLORING MITOMIRS IN BREAST CANCER: AN IN-VITRO STUDY OF THEIR EMERGING ROLES.
- Authors
TOKGÜN, Pervin Elvan; TOMATIR, Ayşe Gaye
- Abstract
Objective: Breast cancer is associated with a 5% genetic predisposition in women. Mitochondria play a role in important cellular events such as metabolism, cell death, and inflammation. Recent studies have highlighted precursor micro-RNA (pre-miRNA) to be located in mitochondria as well as mature miRNA. This study aims to reveal the occurrence of mitochondrial miRNA (mitomiR) in breast cancer cells. Materials and Methods: The study has prepared the mitochondrial fractions using the magnetic-activated cell sorting (MACS) method and performed small RNA (sRNA) sequencing. Results: The study has identified known and novel mitomiR sequences aligned to the mitochondrial genome. Conclusion: Identifying new mitomiRs can provide significant contributions and illuminate the molecular mechanism underlying mitomiR biogenesis.
- Subjects
MITOCHONDRIAL DNA; BREAST cancer; NON-coding RNA; MICRORNA; CELL death; CANCER cells
- Publication
Journal of Istanbul Faculty of Medicine / İstanbul Tıp Fakültesi Dergisi, 2023, Vol 86, Issue 1, p69
- ISSN
1305-6441
- Publication type
Article
- DOI
10.26650/IUITFD.1200910