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- Title
Deficiency of MMP-10 Aggravates the Diseased Phenotype of Aged Dystrophic Mice.
- Authors
Baraibar-Churio, Arantxa; Bobadilla, Míriam; Machado, Florencio J. D.; Sáinz, Neira; Roncal, Carmen; Abizanda, Gloria; Prósper, Felipe; Orbe, Josune; Pérez-Ruiz, Ana
- Abstract
Matrix metalloproteinases (MMPs) have been implicated in the progression of muscular dystrophy, and recent studies have reported the role of MMP-10 in skeletal muscle pathology of young dystrophic mice. Nevertheless, its involvement in dystrophin-deficient hearts remains unexplored. Here, we aimed to investigate the involvement of MMP-10 in the progression of severe muscular dystrophy and to characterize MMP-10 loss in skeletal and cardiac muscles of aged dystrophic mice. We examined the histopathological effect of MMP-10 ablation in aged mdx mice, both in the hind limb muscles and heart tissues. We found that MMP-10 loss compromises survival rates of aged mdx mice, with skeletal and cardiac muscles developing a chronic inflammatory response. Our findings indicate that MMP-10 is implicated in severe muscular dystrophy progression, thus identifying a new area of research that could lead to future therapies for dystrophic muscles.
- Subjects
MATRIX metalloproteinases; MYOCARDIUM; MUSCULAR dystrophy; SKELETAL muscle; HINDLIMB; FACIOSCAPULOHUMERAL muscular dystrophy
- Publication
Life (2075-1729), 2021, Vol 11, Issue 12, p1398
- ISSN
2075-1729
- Publication type
Article
- DOI
10.3390/life11121398