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- Title
Preferential activation of helper/inducer T lymphocytes in autoimmune chronic active hepatitis.
- Authors
Lobo-Yeo, Ava; Alviggi, L.; Mieli-Vergani, Giorgina; Portmann, B.; Mowat, A.P.; Vergani, D.
- Abstract
We found a significant increase of activated circulating T lymphocytes expressing interleukin 2 receptor (IL-2r) (mean ±s,e,m, 11.0±1.1%) or DR antigen (5.0 ±0.49%) in patients with autoimmune chronic active hepatitis (CAH) starling in childhood when compared lo healthy controls (0.14 ±0.09%. P<0.001 and 2.8±0.06%, P<001), Patients with liver disorders due to Wilson's disease (IL-2r 0.64±0.25%, DR 3.5 ±0.22%) Or alpha-l-antitrypsin deficiency (IL-2r 0.1±0.06%. DR 2.8 ± 0.35%) had levels similar to conirots. Levels of both IL-2r and DR positive T lymphocytes were higher in patients with uncontrolled CAH (IL-2r 18.0± 1.01%; DR 6.3±0.78%) than in patients with inactive disease (IL-2r 3.2±1.4%. P<0.001: DR 3.0 ± 0 13% .P<0.01), In patients with active disease levels of IL-2r positive cells were higher than DR positive cells ( P <0.001). Only 21 % of activated T cells coexpressed the two markers of activation. Sixty-seven percent of IL-2r positive T lymphocytes were helper/inducer and 25% suppressor/cytotoxic. while 66% of the DR positive T cells were suppressor/cytotoxic and 3I'M, helper/inducer. The finding that the highest levels of activated T lymphocytes are present in patients with uncontrolled CAH suggests that these cells are involved in its pathogenesis. The preferential increase of activated helper/inducer cells might explain the enhanced immune reactivity characteristic of autoimmune CAH.
- Subjects
LYMPHOCYTES; LEUCOCYTES; AUTOIMMUNE diseases; LIVER diseases; HEPATITIS; COMMUNICABLE diseases
- Publication
Clinical & Experimental Immunology, 1987, Vol 67, Issue 1, p95
- ISSN
0009-9104
- Publication type
Article