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- Title
Reticuloendothelial Fc receptor function in SLE patients. I. Primary HLA linked defect or acquired dysfunction secondary to disease activity?
- Authors
van der Woude, F. J.; van der Giessen, M.; Kallenberg, C. G. M.; Ouwehand, W.; Beekhuis, H.; Beelen, J. M.; van Son, W. J.; Hoedemaeker, J.; van der Hem, G. K.; The, T. H.
- Abstract
Reticuloendothelial system (RES) Fc receptor-mediated immune clearance was measured in 18 patients with systemic lupus erythematosus (SLE). Only two patients, with major disease activity, had a prolonged T½ of the blood disappearance curve of injected IgG coated red cells in comparison to 22 healthy controls. Circulating immune complexes (CIC) were studied with three methods: PEG precipitation, Clq-ELISA and the indirect granulocyte phagocytosis test (IGFT). The T½ of the blood disappearance curve related significantly to the IGFT (r=0.55, P <0.05) and not to the PEG and Clq-ELISA test. Although HLA-DR3 phenotype frequency was significantly increased in our SLE population (P < 0.05), it was not related to Fc receptor function. Similarly, HLA-DR2 phenotype was not related to RES Fc receptor function. These data do not support the concept that a genetic HLA linked defect in reticuloendothelial Fc receptor function is a primary cause of SLE, predisposing the inflicted individual to immune complex deposition. However, Fc receptor-mediated immune clearance seems to be related to disease activity itself and to levels of CIC.
- Subjects
SYSTEMIC lupus erythematosus; IMMUNE response; ENZYME-linked immunosorbent assay; GENETICS; AUTOIMMUNE diseases; PHENOTYPES; PATIENTS
- Publication
Clinical & Experimental Immunology, 1984, Vol 55, Issue 3, p473
- ISSN
0009-9104
- Publication type
Article