We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Functional assessment of T and B lymphocytes in patients with selective IgM deficiency.
- Authors
de la Concha, E. G.; Garcia-Rodriguez, Maria C.; Zabay, J. M.; Laso, Maria T.; Alonso, F.; Bootello, A.; Fontan, G.
- Abstract
Two patients with selective IgM deficiency were studied. Both presented with dermatitis, chronic diarrhoea, recurrent respiratory infections, failure to thrive, elevated serum IgE levels and in vivo impairment of antibody production. No phagocytic or complement abnormalities were found. B lymphocytes with surface IgM were present in normal or high percentage in peripheral blood, and produced normal amounts of IgM in vivo when co-cultured with normal T cells. Patients T cells did not show excess suppressor function in vitro but had a decreased helper activity for IgM, IgG and IgA production. It is suggested that both patients have an extensive humoral immune deficiency that might be caused by the immunoregulatory T cell defect.
- Subjects
LYMPHOCYTES; B cells; T cells; IMMUNOGLOBULIN M; IMMUNODEFICIENCY; FAILURE to thrive syndrome; SERUM
- Publication
Clinical & Experimental Immunology, 1982, Vol 50, Issue 3, p670
- ISSN
0009-9104
- Publication type
Article