We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Prognostic impact of PD-L1 expression in primary gastric and intestinal diffuse large B-cell lymphoma.
- Authors
Ishikawa, Eri; Nakamura, Masanao; Shimada, Kazuyuki; Tanaka, Tsutomu; Satou, Akira; Kohno, Kei; Sakakibara, Ayako; Furukawa, Kazuhiro; Yamamura, Takeshi; Miyahara, Ryoji; Nakamura, Shigeo; Kato, Seiichi; Fujishiro, Mitsuhiro
- Abstract
<bold>Background: </bold>Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease and the most common gastrointestinal lymphoma. The prognostic/predictive indicators among patients with gastric and intestinal DLBCL (giDLBCL) are controversial beyond their anatomical sites. We compared giDLBCL cases and investigated the clinical utility of newly emerging indicators with an emphasis on programmed cell death ligand 1 (PD-L1) expression.<bold>Methods: </bold>This retrospective study included 174 patients with primary gastric (n = 129) or intestinal (n = 45) DLBCL treated with rituximab-containing chemotherapy between 1995 and 2018.<bold>Results: </bold>Compared with gastric DLBCL (gDLBCL) cases, patients with intestinal DLBCL (iDLBCL) had a significantly higher rate of advanced Lugano stage (71% vs 37%, P < 0.001), perforation (13% vs. 0.8%, P = 0.001), PD-L1 expression on microenvironment immune cells (miPD-L1, 70% vs 46%, P = 0.008), CD10 positivity (47% vs 28%, P = 0.027), and CD5 positivity (9% vs 1.6%, P = 0.040). The iDLBCL patients showed significantly worse progression-free survival (PFS) and overall survival (OS) than gDLBCL cases (P = 0.0338 and P = 0.0077, respectively). PD-L1 expression on tumor cells was detected in only 3 (2%) of 174 cases with early relapse and/or an aggressive clinical course; whereas, miPD-L1-positive cases had significantly better OS than the miPD-L1-negative gDLBCL and iDLBCL cases (P = 0.0281 and P = 0.0061, respectively). Multivariate analysis revealed that miPD-L1 negativity (P = 0.030) was an independent adverse prognostic factor for OS in giDLBCL.<bold>Conclusions: </bold>The anatomical site of disease did not influence outcome in giDLBCL cases treated with rituximab-containing chemotherapy; while, miPD-L1 expression had a favorable impact on the outcome.
- Subjects
LUGANO (Switzerland); DIFFUSE large B-cell lymphomas; PROGRESSION-free survival; MULTIVARIATE analysis; THERAPEUTIC use of antineoplastic agents; INTESTINAL tumors; STOMACH tumors; IMMUNOHISTOCHEMISTRY; B cell lymphoma; PROGNOSIS; RETROSPECTIVE studies; IN situ hybridization; SURVIVAL analysis (Biometry); LONGITUDINAL method
- Publication
Journal of Gastroenterology, 2020, Vol 55, Issue 1, p39
- ISSN
0944-1174
- Publication type
journal article
- DOI
10.1007/s00535-019-01616-3