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- Title
Endothelial Function in COPD Is in an Intermediate Position Between Healthy Subjects and Coronary Artery Disease Patients and Is Related to Physical Activity.
- Authors
Bernardi, Eva; Merlo, Carlotta; Cogo, Annalisa
- Abstract
Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of ischemic heart disease. Endothelial dysfunction may play a role in the onset of cardiovascular event. Previous studies showed an impaired endothelial function (measured by flow-mediated dilation, FMD) in COPD patients compared to healthy subjects. To the best of our knowledge no study has compared FMD in COPD and in cardiac (coronary artery disease, CAD) patients. We aimed to assess FMD in healthy subjects, COPD, CAD, and COPD + CAD. The main result is that FMD in COPD is reduced and is in an intermediate position between healthy subjects and CAD or COPD + CAD; this impairment can contribute to explain the higher prevalence of cardiovascular disease in COPD. The only determinant independently associated with FMD in all subjects is the physical activity level, irrespective of the traditional risk factors (i.e., smoke, dyslipidemia, hypertension).
- Subjects
OBSTRUCTIVE lung diseases; LUNG diseases; RESPIRATORY obstructions; ASTHMA; CORONARY disease
- Publication
Lung, 2018, Vol 196, Issue 6, p669
- ISSN
0341-2040
- Publication type
Article
- DOI
10.1007/s00408-018-0168-9