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- Title
Procalcitonin to Detect Bacterial Infections in Critically Ill Pediatric Patients.
- Authors
Jacobs, David M.; Holsen, Maya; Chen, Shirley; Fusco, Nicholas M.; Hassinger, Amanda B.
- Abstract
The diagnostic power of procalcitonin (PCT) in the pediatric intensive care unit (PICU) is uncertain. This study aimed to determine the diagnostic ability of PCT to detect serious bacterial infections (SBI) in a heterogeneous PICU population. This was a retrospective cohort study of patients on whom a PCT level was obtained within 48 hours of admission to a PICU from 2013 to 2015. Discriminatory ability of PCT to predict SBI was examined by test and receiver operating characteristics (AUC [area under the curve]-ROC). Seventy-five patients were included and 28 (37%) had an SBI (median PCT = 6.48 ng/mL) compared with 47 (63%) in the noninfection group (median PCT = 0.23 ng/mL, P < .0001). PCT was able to adequately predict SBI (AUC-ROC = 0.83, 95% CI 0.74-0.93; P < .0001), and a PCT 埙1.28 ng/mL was the optimal threshold to detect SBI with a positive predictive value of 76.7% and negative predictive value of 88.9%. PCT adequately predicted SBI in a heterogeneous PICU population and may be useful for minimizing antibiotic consumption.
- Subjects
DIAGNOSIS of bacterial diseases; CALCITONIN; COMPARATIVE studies; CONFIDENCE intervals; CRITICALLY ill; INTENSIVE care units; LONGITUDINAL method; PATIENTS; PEDIATRICS; PROBABILITY theory; PREDICTIVE tests; RETROSPECTIVE studies; RECEIVER operating characteristic curves; CHILDREN
- Publication
Clinical Pediatrics, 2017, Vol 56, Issue 9, p821
- ISSN
0009-9228
- Publication type
Article
- DOI
10.1177/0009922817715937