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- Title
PVA-Based Electrospun Biomembranes with Hydrolyzed Collagen and Ethanolic Extract of Hypericum perforatum for Potential Use as Wound Dressing: Fabrication and Characterization.
- Authors
García-Hernández, Alitzel Belém; Morales-Sánchez, Eduardo; Berdeja-Martínez, Blanca M.; Escamilla-García, Monserrat; Salgado-Cruz, Ma. Paz; Rentería-Ortega, Minerva; Farrera-Rebollo, Reynold R.; Vega-Cuellar, Miguel A.; Calderón-Domínguez, Georgina
- Abstract
Biological, physicochemical, structural, and thermal properties of PVA-based electrospun wound dressings added with hydrolyzed collagen (HC) and different concentrations of Hypericum perforatum ethanolic extract (EEHP) were studied. Membrane characterization was carried out by X-ray diffraction, Fourier infrared spectroscopy, differential scanning calorimetry, barrier properties, scanning electron microscopy, image analysis (diameter and pore size), as well as antimicrobial and anti-inflammatory activities. Results showed that the PVA/HC/EEHP materials, fabricated under controlled conditions of temperature and humidity, generated fiber membranes with diameters between 140–390 nm, adequate porosity and pore size for cell growth (67–90% and 4–16 µm, respectively), and good barrier properties (0.005–0.032 g·m−2 s−1) to be used in the treatment of conditions on the skin, and was even better than some commercial products. Finally, they showed to have anti-inflammatory (>80%), and antimicrobial activity against S. aureus and S. epiderm. Furthermore, higher crystalline structure was observed according to the EEHP concentration. In addition, this is the first report in which PVA/HC/EEHP membranes are successfully fabricated and characterized.
- Subjects
HYPERICUM perforatum; COLLAGEN; BIOLOGICAL membranes; COMPOSITE membranes (Chemistry); DIFFERENTIAL scanning calorimetry; SCANNING electron microscopy
- Publication
Polymers (20734360), 2022, Vol 14, Issue 10, p1981
- ISSN
2073-4360
- Publication type
Article
- DOI
10.3390/polym14101981