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- Title
Antileishmanial Activity of a New ent-Kaurene Diterpene Glucoside Isolated from Leaves of Xylopia excellens R.E.Fr. (Annonaceae).
- Authors
de Alencar, Danielle C.; Silva, Felipe M. A. da; de Almeida, Richardson A.; Costa, Emmanoel V.; Dutra, Lívia M.; Barison, Andersson; Volpato, Helito; Nakamura, Celso V.; Koolen, Hector H. F.; de Souza, Afonso Duarte L.; Pinheiro, Maria Lúcia B.
- Abstract
This work describes a new ent-kaurene diterpene glucoside, 7β-O-β-D-glucopyranoside-ent-kaur-16- ene, from the leaves of Xylopia excellens R.E.Fr. (Annonaceae). The compound showed high in vitro antileishmanial activity (IC50 of 15.23 ± 0.64 µg/mL) towards promastigote forms of Leishmania amazonensis, and low cytotoxicity against J774A1 cells (SI of 1.96).
- Subjects
DITERPENES; GLUCOSIDES; GLUCOPYRANOSIDE; XYLOPIA; ANNONACEAE; LEISHMANIA
- Publication
Records of Natural Products, 2018, Vol 12, Issue 2, p190
- ISSN
1307-6167
- Publication type
Article
- DOI
10.25135/rnp.16.17.06.111