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- Title
MARJOLIN ULCER – DEVELOPMENT OF SQUAMOUS CELL CARCINOMA IN A CHRONIC WOUND: A CASE REPORT.
- Authors
Kovačević, Iva; Massari, Larisa Prpić
- Abstract
Background: Marjolin’s ulcer is a rare entity related to squamous cell carcinoma of the skin that develops in the area of a chronic wound, and has a more aggressive course, with infiltrative growth, a higher recurrence rate, a higher metastatic potential, and a higher mortality rate. Aim: To raise awareness of the possibility of developing squamous cell carcinoma in the area of chronic wounds, and to discuss therapeutic options, since due to the specifics of Marjolin’s ulcer, there is no unambiguous therapeutic approach. Case Report: A 77-year-old patient was referred to the Dermatovenereology Clinic for an ulcer of her right lower leg. She stated that the ulceration on the lower leg lasted and recurred for many years, and the recent verrucous ulcerated change persisted for more than a year. After two months of unsuccessful conservative therapy, a biopsy of the chronic wound was performed, and the presence of squamous cell carcinoma was found. Due to the large local finding and the absence of metastases, it was decided that the patient receives primary radical radiotherapy. Three months after radiotherapy, a major lower leg defect was described which, compared to the preoperative finding, indicated regression of the tumor process. A week later, a pronounced edge of the change was observed. A biopsy was performed, but no recurrence of the tumor was found. One year after radiotherapy, a chronic wound without recurrence of squamous cell carcinoma but with delayed healing was described. Conclusion: Although Marjolin’s ulcer, an aggressive form of squamous cell carcinoma, is a rare entity, it should be considered when the chronic wound is not healing, in the absence of risk factors for ulceration. Future research is needed to determine a standard therapeutic approach, as well as the optimal follow-up period.
- Subjects
SQUAMOUS cell carcinoma; CHRONIC wounds &; injuries; ULCERS; HEALING; CONSERVATIVE treatment
- Publication
Lijecnicki Vjesnik, 2023, Vol 145, p91
- ISSN
0024-3477
- Publication type
Article
- DOI
10.26800/LV-145-supl3-4