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- Title
A Herpes Simplex Virus (HSV)-2 Single-Cycle Candidate Vaccine Deleted in Glycoprotein D Protects Male Mice From Lethal Skin Challenge With Clinical Isolates of HSV-1 and HSV-2.
- Authors
Burn, Clare; Ramsey, Natalie; Garforth, Scott J.; Almo, Steven; Jacobs Jr., William R.; Herold, Betsy C.; Jacobs, William R Jr.
- Abstract
Herpes simplex virus (HSV) infections manifest as recurrent oral or genital mucosal lesions, meningoencephalitis, corneal blindness, and perinatal disease. Subunit vaccines have advanced into the clinic without success. None were tested preclinically in male mice. We compared a single-cycle candidate vaccine deleted in HSV-2 glycoprotein D (ΔgD-2) and subunit gD-2 or gD-1 protein vaccines in a male murine skin model. The ΔgD-2 provided complete protection against 10 times the lethal dose of HSV-1 or HSV-2 clinical isolates, and no latent virus was detected, whereas gD-1- and gD-2-adjuvanted proteins provided little or no protection. Protection correlated with Fc receptor activating but not neutralizing antibody titers.
- Subjects
HERPES simplex virus; MENINGOENCEPHALITIS; GLYCOPROTEINS; BLIND people; VIRAL vaccines; MICE; ANIMAL models in research; HERPES simplex prevention; ANIMAL experimentation; BIOLOGICAL models; CELL receptors; HERPESVIRUSES; IMMUNOGLOBULINS; GENETIC mutation; PROTEINS; SURVIVAL analysis (Biometry); VACCINES; VIRAL antibodies
- Publication
Journal of Infectious Diseases, 2018, Vol 217, Issue 5, p754
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jix628