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- Title
Gingival Crevicular Fluid, Serum Levels of Receptor Activator of Nuclear Factor-κB Ligand, Osteoprotegerin, and Interleukin-17 in Patients With Rheumatoid Arthritis and Osteoporosis and With Periodontal Disease.
- Authors
Gümüş, Pınar; Buduneli, Eralp; Bıyıkoğlu, Başak; Aksu, Kenan; Saraç, Fulden; Nile, Christopher; Lappin, David; Buduneli, Nurcan
- Abstract
Background: This study is performed to evaluate gingival crevicular fluid (GCF) and serum levels of soluble receptor activator of nuclear factor-KB ligand (sRANKL), interleukin (IL)-17A, IL-17E, IL-17F, iL-17A/F, and osteoprotegerin (OPG) in women with rheumatoid arthritis (RA), osteoporosis (OPR), and those who are systemically healthy (SH), all with periodontal disease. Methods: GCF and serum samples were obtained before any periodontal intervention from 17 women with RA, 19 with OPR, and 13 who were SH with periodontitis. Full-mouth clinical periodontal measurements were recorded, sRANKL, OPG, and IL-17 levels were determined by enzyme-linked immunosorbent assay. Results: Clinical periodontal measurements were similar in the three study groups. Although the total amounts of GCF albumin, OPG, IL-17A, and 1L-17A/F were similar in the study groups, there were statistically significant differences in GCF concentrations of sRANKL, OPG, iL-17A, IL-17E, IL-17F, and IL-17A/F. The sRANKL/OPG ratios were significantly higher in the RA group than in the OPR and SH groups (P <0.05). Serum sRANKL, sRANKL/OPG, and IL-17A/IL-17E ratios were significantly higher, whereas OPG concentrations were significantly lower in the RA group compared to other groups (P <0.05). Serum IL-17A concentrations were significantly higher in the RA and OPR groups than in the SH group (P <0.05). Conclusion: Increased inflammatory mediator levels in patients with RA, despite the long-term use of various anti-inflammatory drugs, suggest that these patients may have a propensity to overproduce these inflammatory mediators.
- Subjects
GINGIVAL fluid; TRANCE protein; OSTEOPROTEGERIN; INTERLEUKIN-17; RHEUMATOID arthritis; OSTEOPOROSIS; PERIODONTAL disease
- Publication
Journal of Periodontology, 2013, Vol 84, Issue 11, p1627
- ISSN
0022-3492
- Publication type
Article
- DOI
10.1902/jop.2013.120595