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- Title
Cardiovascular <sup>18</sup>F-fluoride positron emission tomography-magnetic resonance imaging: A comparison study.
- Authors
Andrews, Jack P. M.; MacNaught, Gillian; Moss, Alastair J.; Doris, Mhairi K.; Pawade, Tania; Adamson, Philip D.; van Beek, Edwin J. R.; Lucatelli, Christophe; Lassen, Martin L.; Robson, Philip M.; Fayad, Zahi A.; Kwiecinski, Jacek; Slomka, Piotr J.; Berman, Daniel S.; Newby, David E.; Dweck, Marc R.
- Abstract
<bold>Background: </bold>18F-Fluoride uptake denotes calcification activity in aortic stenosis and atherosclerosis. While PET/MR has several advantages over PET/CT, attenuation correction of PET/MR data is challenging, limiting cardiovascular application. We compared PET/MR and PET/CT assessments of 18F-fluoride uptake in the aortic valve and coronary arteries.<bold>Methods and Results: </bold>18 patients with aortic stenosis or recent myocardial infarction underwent 18F-fluoride PET/CT followed immediately by PET/MR. Valve and coronary 18F-fluoride uptake were evaluated independently. Both standard (Dixon) and novel radial GRE) MR attenuation correction (AC) maps were validated against PET/CT with results expressed as tissue-to-background ratios (TBRs). Visually, aortic valve 18F-fluoride uptake was similar on PET/CT and PET/MR. TBRMAX values were comparable with radial GRE AC (PET/CT 1.55±0.33 vs. PET/MR 1.58 ± 0.34, P = 0.66; 95% limits of agreement - 27% to + 25%) but performed less well with Dixon AC (1.38 ± 0.44, P = 0.06; bias (-)14%; 95% limits of agreement - 25% to + 53%). In native coronaries, 18F-fluoride uptake was similar on PET/MR to PET/CT regardless of AC approach. PET/MR identified 28/29 plaques identified on PET/CT; however, stents caused artifact on PET/MR making assessment of 18F-fluoride uptake challenging.<bold>Conclusion: </bold>Cardiovascular PET/MR demonstrates good visual and quantitative agreement with PET/CT. However, PET/MR is hampered by stent-related artifacts currently limiting clinical application.
- Subjects
POSITRON emission; AORTIC valve; AORTIC stenosis; CLINICAL medicine; DIAGNOSTIC imaging; WATER fluoridation; HEART valve prosthesis implantation; MAGNETIC resonance angiography; MYOCARDIAL infarction; RADIOPHARMACEUTICALS; RESEARCH funding; DEOXY sugars
- Publication
Journal of Nuclear Cardiology, 2021, Vol 28, Issue 5, p1
- ISSN
1071-3581
- Publication type
journal article
- DOI
10.1007/s12350-019-01962-y