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- Title
Aryl‐hydrocarbon receptor agonist: A novel topical therapeutic approach for inflammatory skin diseases.
- Authors
Aoki, Valeria; Orfali, Raquel Leão
- Abstract
Atopic dermatitis: In one single-centre study, 34 AD patients randomized (1:1:1) to tapinarof 0.5%, 1% or vehicle were treated bid for 4 weeks, showing that 50% of AD patients in both treatment groups achieved an IGA of clear or almost clear compared to 8.3% for the vehicle group (at week 5). The broadening of novel therapeutic options for chronic inflammatory skin diseases such as atopic dermatitis (AD) and psoriasis (PSO), known to be associated with dysregulation of the immune response, systemic comorbidities and a reduced quality of life for patients and caretakers, offers better chances for long-lasting disease control.[[1]] Recent advances in clarifying the mechanisms that lead to the immune imbalance in both diseases indicate a predominant IL-23/IL-17A/IL36 pathway in psoriasis, and a predominant Th2 IL-4/IL-13, with the participation of IL-17 and IL-22 axis in atopic dermatitis.[[1]] The development of targeted-oriented therapies such as biologics and small molecule inhibitors (SMIs) changed the traditional management of such inflammatory conditions, therefore optimizing the standard of care in both diseases.[[1]] One of the new foci of targeted therapies for inflammatory skin diseases is the aryl-hydrocarbon receptor (AhR)/AhR-nuclear translocator (ARNT) system, which works as a sensor for exogenous and endogenous molecules. The key point of this review indicates the profile of tapinarof in psoriasis and AD, as follows[4]: Psoriasis: A phase 2, single-centre clinical trial, showed a rapid start of action in topically applied bid tapinarof 1% group than vehicle.
- Subjects
SKIN diseases; THERAPEUTICS; ARYL hydrocarbon receptors
- Publication
Journal of the European Academy of Dermatology & Venereology, 2023, Vol 37, Issue 6, p1093
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/jdv.19080