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- Title
Long-term follow-up study of patients with gastric adenomas with malignant transformation. An immunohistochemical and histochemical analysis.
- Authors
Kolodziejczyk, Piotr; Yao, Takashi; Oya, Masafumi; Nakamura, Shotaro; Utsunomiya, Takashi; Ishikawa, Tsuyoshi; Tsuneyoshi, Masazumi; Kolodziejczyk, P; Yao, T; Oya, M; Nakamura, S; Utsunomiya, T; Ishikawa, T; Tsuneyoshi, M
- Abstract
<bold>Background: </bold>Little is known about the changes in the immunohistochemical and histochemical characteristics that take place during the malignant transformation of gastric adenoma (GA).<bold>Methods: </bold>Nine patients with GA who developed carcinoma (Group A) and 33 who did not (Group B) during an equivalent follow-up period (mean, 76.4 months; range, 38-166 months) were studied. Tissue sections from these patients were stained for p53, c-erbB-2, bcl-2, carbohydrate antigen 19-9 (CA 19-9), carcinoembryonic antigen (CEA), and proliferating cell nuclear antigen (PCNA), and by high iron diamine-alcian blue staining. The gastric or intestinal phenotypes of the GA cells were evaluated histochemically by paradoxical concanavalin A and galactose oxidase-Schiff reactions.<bold>Results: </bold>In Group A, the following were more frequent; severe dysplasia (77.8% vs. 0%, P < 0.001), villous structures (66.7% vs. 9.1%, P < 0.05), sulfomucin secretion (88.9% vs. 39.4%, P < 0.05) and mixed gastric-intestinal phenotype (77.8% vs. 9.1%, P < 0.001). The development of carcinoma in Group A positively correlated with an increase in p53 expression and PCNA-labeling index. None of the adenomas was positive for c-erbB-2, but four of nine carcinomas showed positive reactions.<bold>Conclusions: </bold>Mucin histochemistry of GA may be of some value in assessing the potential for subsequent carcinoma. Immunoexpression of c-erbB-2, bcl-2, CA 19-9, and CEA have only limited value. In contrast to p53, the immunoexpression of c-erbB-2 is a late event in the malignant transformation of GA.
- Subjects
PROTEIN metabolism; STOMACH tumors; PROTEINS; CELL differentiation; IMMUNOHISTOCHEMISTRY; ONCOGENES; NEOPLASTIC cell transformation; ADENOMA; CELL receptors; CANCER; PREVENTIVE Cardiovascular Nurses Association; PROTEIN-tyrosine kinases; GENES; TUMOR antigens; LONGITUDINAL method; CARRIER proteins; METABOLISM
- Publication
Cancer (0008543X), 1994, Vol 74, Issue 11, p2896
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19941201)74:11<2896::AID-CNCR2820741103>3.0.CO;2-P