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- Title
Proliferative potential of brain tumors. Analyses with Ki-67 and anti-DNA polymerase alpha monoclonal antibodies, bromodeoxyuridine labeling, and nuclear organizer region counts.
- Authors
Shibuya, Makoto; Ito, Satoyuki; Miwa, Tetsuro; Davis, Richard L.; Wilson, Charles B.; Hoshino, Takao; Shibuya, M; Ito, S; Miwa, T; Davis, R L; Wilson, C B; Hoshino, T
- Abstract
Histochemical analyses with Ki-67 and anti-DNA polymerase alpha monoclonal antibodies were done, and argyrophilic nucleolar organizer regions (Ag-NOR) were counted to estimate the proliferative potential of 200 brain tumors. The findings were compared with the bromodeoxyuridine labeling index (BrdU LI), or S-phase fraction. The proliferating cell indexes (PCI), determined by Ki-67 and anti-DNA polymerase alpha monoclonal antibodies were higher and Ag-NOR more numerous in medulloblastomas, glioblastomas, and metastatic carcinomas than in astrocytomas or meningiomas. The Ki-67 and DNA polymerase alpha PCI correlated with the BrdU LI (r = 0.87 and r = 0.84, respectively) and with each other (r = 0.94). The number of Ag-NOR correlated less strongly with these indexes in some tumors. These findings suggest that Ki-67 and anti-DNA polymerase alpha monoclonal antibodies may be useful for estimating the proliferative potential of individual tumors in routine clinical practice. The number of Ag-NOR, however, does not always reflect the growth potential of each tumor.
- Publication
Cancer (0008543X), 1993, Vol 71, Issue 1, p199
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19930101)71:1<199::AID-CNCR2820710131>3.0.CO;2-S