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- Title
Anthropometric Risk Factors for Differentiated Thyroid Cancer in Young Men and Women From Eastern France: A Case-Control Study.
- Authors
Xhaard, Constance; Vathaire, Florent de; Cléro, Enora; Maillard, Stéphane; Ren, Yan; Borson-Chazot, Françoise; Sassolas, Geneviève; Schvartz, Claire; Colonna, Marc; Lacour, Brigitte; Danzon, Arlette; Velten, Michel; Marrer, Emilie; Bailly, Laurent; Barjoan, Eugènia Mariné; Schlumberger, Martin; Orgiazzi, Jacques; Adjadj, Elisabeth
- Abstract
The incidence of thyroid cancer has risen over the past decade, along with a rise in obesity.We studied the role of anthropometric risk factors for differentiated thyroid cancer at the time of diagnosis and at age 20 years in a casecontrol study conducted in eastern France between 2005 and 2010. The study included 761 adults diagnosed with differentiated thyroid cancer before 35 years of age between 2002 and 2006. They were matched with 825 controls from the general population. Odds ratios were calculated using conditional logistic regression models and were reported for all participants, those with papillary cancer only, and women only. The risk of thyroid cancerwas higher for participants with a high body surface area (BSA), great height, or excess weight and for women with a high body fat percentage. Conversely, no significant association was found between body mass index and the risk of thyroid cancer. In the present study, we provide further evidence of the role of BSA and excess weight in the risk of thyroid cancer. These epidemiologic observations should be confirmed by further exploration of the biological mechanisms responsible for the associations of obesity and BSA with thyroid cancer.
- Subjects
FRANCE; OBESITY complications; ADIPOSE tissues; ANTHROPOMETRY; CONFIDENCE intervals; RESEARCH funding; LOGISTIC regression analysis; BODY mass index; THYROID gland tumors; CASE-control method; BODY surface area; DATA analysis software; DESCRIPTIVE statistics; ODDS ratio; DIAGNOSIS; TUMOR risk factors
- Publication
American Journal of Epidemiology, 2015, Vol 182, Issue 3, p202
- ISSN
0002-9262
- Publication type
Article
- DOI
10.1093/aje/kwv048