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- Title
A Polymorphism That Reduces RANTES Expression Is Associated with Protection from Death in HIV-Seropositive Ugandans with Advanced Disease.
- Authors
Cooke, Graham S.; Tosh, Kerrie; Ramaley, Patricia A.; Kaleebu, Pontiano; Zhuang, Joanna; Nakiyingi, Jessica S.; Watera, Christine; Gilks, Charles F.; French, Neil; Whitworth, James A. G.; Hill, Adrian V. S.
- Abstract
We investigated the effect of RANTES polymorphisms on human immunodeficiency virus type 1 (HIV-1) disease progression in an urban population of Uganda. HIV-positive individuals homozygous for the INT1.1C polymorphism, which had been associated previously with low RANTES expression, were less likely to die than were those with other genotypes (hazard ratio, 0.53 [95% confidence interval, 0.33– 0.83]; P = .007). This report of a non-human leukocyte antigen genetic association with HIV-1 and/or acquired immunodeficiency syndrome disease progression in an African population reveals a genetic effect different from that reported elsewhere for African Americans and may impact therapeutic strategies targeting the RANTES pathway in HIV infection.
- Subjects
T cells; CELL-mediated lympholysis; HIV; HIV-positive persons; IMMUNE response; ANTIVIRAL agents; GENETIC polymorphisms; IMMUNODEFICIENCY
- Publication
Journal of Infectious Diseases, 2006, Vol 194, Issue 5, p666
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/505875