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- Title
Dendritic and Natural Killer Cell Subsets Associated with Stable or Declining CD4<sup>+</sup> Cell Counts in Treated HIV-1-Infected Children.
- Authors
Azzoni, L.; Rutstein, R. M.; Chehimi, J.; Farabaugh, M. A.; Nowmos, A.; Montaner, L. J.
- Abstract
Background. Natural killer (NK) cells and plasmacytoid and myeloid dendritic cells (DCs) are depleted, and their function impaired, in advanced adult human immunodeficiency virus (HIV)-1 infection. Studies in perinatally infected children are lacking. Methods. Percentages of NK cells and plasmacytoid and myeloid DCs were evaluated by flow cytometry. Forty children with perinatal HIV- 1 infection were compared with 11 age-matched, uninfected children. Plasmacytoid and myeloid DC function was evaluated by activation-induced cytokine secretion. Results. Virally suppressed children had normal levels of circulating plasmacytoid and myeloid DCs and total NK cells but had sustained depletion of a mature (CD3-/161+/56+/16+) NK cell subset and decreased interferon- α secretion by plasmacytoid DCs. Despite similar viral loads, percentages of myeloid and plasmacytoid DCs and mature NK cells were significantly lower in viremic children with a history of decreasing CD4+ cell percentages, compared with children with stable CD4+ cell counts. Conclusions. Children achieve partial reconstitution of myeloid and plasmacytoid DCs and NK cells during viral suppression; irrespective of viral load, a clinical history of decreasing CD4+ cell percentage is associated with greater depletion of these subsets. We hypothesize that the evaluation of selected innate-immunity effector cells may serve as a marker of CD4+ cell loss in pediatric HIV- 1 infection.
- Subjects
KILLER cells; DENDRITIC cells; HIV infections; HIV; CELL-mediated cytotoxicity; IMMUNITY; ANTINEOPLASTIC agents
- Publication
Journal of Infectious Diseases, 2005, Vol 191, Issue 9, p1451
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/429300