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- Title
β -Herpesvirus (Human Cytomegalovirus and Human Herpesvirus 6) Reactivation in At-Risk Lung Transplant Recipients and in Human Immunodeficiency Virus-Infected Patients.
- Authors
Michaelides, Alexandra; Glare, Eric M.; Spelman, Denis W.; Wesselingh, Steven L.; Hoy, Jennifer F.; Mijch, Anne M.; Kotsimbos, Thomas C.
- Abstract
Human herpesvirus (HHV)-6 is β-herpesvirus-like human cytomegalovirus (HCMV) with the potential to reactivate in immunocompromised persons. HHV-6 and HCMV were assessed in the peripheral blood leukocytes of 26 lung transplant recipients and of 37 human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy, to determine the degree of concordance between HHV-6 and HCMV reactivation in different biologic settings. In the lung transplant recipients (145 samples), HHV-6 was not detected, even though 44 (30%) of 145 samples were from 9 HCMV DNA-positive patients (13 episodes of HCMV pneumonitis). Among the HIV-infected patients (172 samples), HCMV DNA was detected in 29 (17%) of 172 samples from 10 patients (4 episodes of HCMV disease). HHV6 DNA was detected in 2 HIV-infected patients who did not have HCMV detected at that time. These findings suggest that the pathobiologic control mechanisms for these 2 β-herpesviruses may be significantly different.
- Subjects
HUMAN herpesvirus-6; TRANSPLANTATION immunology; HIV infections
- Publication
Journal of Infectious Diseases, 2002, Vol 186, Issue 2, p173
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/341456