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- Title
Treatment outcome of adult patients with Burkitt lymphoma: results using the LMB protocol in Korea.
- Authors
Moon Ki Choi; Hyun Jung Jun; Sung Yoon Lee; Kyung Ha Kim; Do Hyoung Lim; Kihyun Kim; Young Hyeh Ko; Won Seog Kim; Seok Jin Kim; Choi, Moon Ki; Jun, Hyun Jung; Lee, Sung Yoon; Kim, Kyung Ha; Lim, Do Hyoung; Kim, Kihyun; Ko, Young Hyeh; Kim, Won Seog; Kim, Seok Jin
- Abstract
Burkitt lymphoma (BL) is a rare subtype of adult non-Hodgkin lymphoma, so studies on the outcome of adult BL, especially in Asian patients, are scarce. We report our results using the LMB protocol on Korean adult BL patients. Thirty-eight newly diagnosed BL patients were treated with the LMB protocol; 29 males and nine females with a median age of 47 years (range 18-70) were analyzed, and 14 (36.8%) patients had central nervous system or bone marrow involvement. After the induction phase, 28 patients achieved complete response (CR, 73.7%) and five showed partial response (PR, 13.2%). Among those achieving CR, only four showed relapse. All of the non-CR patients died, including five PR and one with progressive disease. The other four patients died because of infection after the first course of induction. The progression-free and overall estimated survival at 5 years was 74.99% and 68.10%, respectively. Of the 12 patients who died, the median survival was 4.43 months (95% confidence interval 1.43-7.43 months). Thus, most deaths occurred shortly after diagnosis, and four patients older than 58 years died after the first induction cycle. Most early deaths were caused by treatment-related morbidity and failure to achieve complete response. B symptoms, advanced age, bone marrow involvement, and St. Jude/Murphy stage IV classification were significantly associated with poor overall survival. In conclusion, the LMB protocol was effective for Korean adult BL patients. However, considering the high incidence of treatment-related deaths and the poor outcome of non-CR patients, risk-adapted modification of the induction phase is warranted.
- Subjects
KOREA; THERAPEUTICS; BURKITT'S lymphoma; PATIENTS; DISEASE complications; HODGKIN'S disease; ANTINEOPLASTIC agents; B cell lymphoma; BLOOD diseases; DOXORUBICIN; CLINICAL drug trials; ETOPOSIDE; METHOTREXATE; PREDNISONE; PROGNOSIS; SEPSIS; VINCRISTINE; TREATMENT effectiveness; PROPORTIONAL hazards models; RETROSPECTIVE studies; CYCLOPHOSPHAMIDE; CYTARABINE; KAPLAN-Meier estimator
- Publication
Annals of Hematology, 2009, Vol 88, Issue 11, p1099
- ISSN
0939-5555
- Publication type
journal article
- DOI
10.1007/s00277-009-0729-3