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- Title
Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway.
- Authors
Hegyi, Eszter; Sahin-Tóth, Miklós; Sahin-Tóth, Miklós
- Abstract
Genetic investigations have provided unique insight into the mechanism of chronic pancreatitis in humans and firmly established that uncontrolled trypsin activity is a central pathogenic factor. Mutations in the PRSS1, SPINK1, and CTRC genes promote increased activation of trypsinogen to trypsin by stimulation of autoactivation or by impairing protective trypsinogen degradation and/or trypsin inhibition. Here we review key genetic and biochemical features of the trypsin-dependent pathological pathway in chronic pancreatitis.
- Subjects
CHRONIC pancreatitis; DIGESTIVE enzymes; TRYPSINOGEN; TRYPSIN inhibitors; CHYMOTRYPSIN; GENETICS; DISEASE susceptibility; GENES; GENETIC mutation; PANCREATITIS; TRYPSIN; ACUTE diseases
- Publication
Digestive Diseases & Sciences, 2017, Vol 62, Issue 7, p1692
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-017-4601-3